Protein structural analysis: features and main advantages
・Reconstructing a 3D-image of a protein in about 1.5 nm resolution
・No need to crystallize samples (vitrification of the sample, free of stain)
・No upper limit to the size of macromolecular complex
・Small amount of sample
・Providing analysis reports along with the data


1. Structural analysis of individual molecules
➡ not the averaged molecular structure, possibility to obtain dynamic structure
2. Reduction of electron beam irradiation and direct electron detector
➡ can be analyzed without destroying the molecular structure
3. Analysis by COMET (constrained maximum entropy tomography)
➡ improvement of image quality by noise removal